Diltiazem is a calcium channel blocker type antihypertensive drug. Diltiazem is a class of calcium channel blockers, used in the treatment of hypertension, angina pectoris and some types of arrhythmia. It is also an effective preventive medication for migraine. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies as well as stability study. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed. This review covers the most recent many analytical methods including spectrophotometric methods, chromatographic method including HPLC and RP HPLC, liquid chromatography tendam mass spectroscopy, colorimetry and potentiometry were reported.
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